Comparative Efficacy and Humoral Responses of an Inactivated Infectious Bursal Disease Virus Vaccine Prepared from a Local Isolate with that of a Commercial Live Vaccine in Layer Birds

Authors

  • MIA Begum Department of Microbiology and Hygiene, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh
  • MA Islam Department of Microbiology and Hygiene, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh
  • ATM Mahbub-E-Elahi Department of Microbiology and Hygiene, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh
  • M Rahman Department of Microbiology and Hygiene, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh
  • MER Bhuiyan Department of Physiology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh

DOI:

https://doi.org/10.3329/bjvm.v2i1.1932

Keywords:

Efficacy, humoral immune response, IBD, inactivated vaccine, live vaccine, layer birds

Abstract

The humoral immune response and efficacy of an inactivated adjuvanted infectious bursal disease virus (IBDV) vaccine prepared with a virulent local isolate was compared with a live commercial IBDV vaccine (Nobilis D78®, Intervet) in 20 layer birds during the period from October to November 2002. These day-old experimental birds were divided into four groups, A, B, C and D, each consisting of 5 birds. Each bird of groups A, B and C was immunized with live IBDV vaccine (Nobilis D78®, Intervet), live + inactivated vaccine, and inactivated IBDV vaccine, respectively at day 7, day 21 and day 28, whereas birds of group D served as unvaccinated controls. The sera of chickens vaccinated with either combined (live + inactivated) or only inactivated IBDV vaccine showed clear band of precipitation with agar gel immunodiffusion test (AGIDT) and higher antibody titre with ELISA. The protection test revealed that the experimentally prepared inactivated IBDV vaccine gave 100% protection against 80% protection in layer birds immunized with live commercial vaccine.

Key words: Efficacy; humoral immune response; IBD: inactivated vaccine; live vaccine; layer birds

doi: 10.3329/bjvm.v2i1.1932

Bangl. J. Vet. Med. (2004). 2 (1) : 37-38

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Issue

Vol. 2 No. 1 (2004)

Section

Avian Medicine