Ginsenoside Rb1, A Component of Panax Ginseng, Ameliorates Selenium Induced Renal Toxicity in Broilers

Abstract

Panax Ginseng (PG) has been widely used as natural product for many years with limited knowledge on its effect on renal dysfunction. Ginsenoside (Rb1) is the most clinically effective derivative of ginseng. The aim of this study was to investigate the protective role of ginsenoside Rb1 on selenium induced renal toxicity in broilers. Forty, one day old chicks acclimatized for 14 days and divided into four groups; negative control, Selenium (Se) treated (0.48 mg Na₂SeO₃/kg b.wt.), Rb1 plus Se treated (100mg Rb1/kg b.wt. & 0.48 mg Na₂SeO₃/kg b.wt.) and Rb1 treated (100 mg Rb1/ kg b.wt.) groups. Levels of blood urea nitrogen, uric acid, creatinine, calcium (Ca), phosphorus (P), magnesium (Mg), sodium (Na), potassium (K), catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) and malondialdehyde (MDA) were estimated. The pretreatment of chickens with Rb1 significantly ameliorate the degenerative effect of selenium over the biochemical parameters, electrolytes and improves the antioxidant activity. Taken together, it could be concluded that the pretreatment of ginsenoside Rb1 has a protective effects against renal injury induced by sodium selenite toxicosis. The ginsenoside Rb1 is thus can be utilized as a useful natural product tool to protect against selenium toxicosis.

DOI: http://dx.doi.org/10.3329/bjvm.v12i2.21274

Bangl. J. Vet. Med. (2014). 12 (2): 127-134