Determination of immune response of imported Newcastle disease virus vaccines in broiler chickens

Authors

  • MS Islam Department of Microbiology and Hygiene, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh
  • AKM Khasruzzaman CP Bangladesh Co. Ltd.
  • MT Hossain Department of Microbiology and Hygiene, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh
  • MT Islam Department of Microbiology and Hygiene and Department of Medicine, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh and
  • MH Chowdhury Department of Microbiology and Hygiene, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh
  • MM Rahman Department of Microbiology and Hygiene, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh
  • MA Zinnah Department of Microbiology and Hygiene, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh
  • NA Banu Department of Microbiology and Hygiene, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh
  • MA Islam Department of Microbiology and Hygiene, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh

DOI:

https://doi.org/10.3329/bjvm.v6i2.2326

Keywords:

Immune response, Newcastle disease, ND vaccines, broiler chickens

Abstract

A study was undertaken to determine the immune response of eight different imported live NDV vaccines in broiler chickens in the Department of Microbiology and Hygiene, Bangladesh Agricultural University, Mymensingh during the period from July to December 2008. A total of 55 broiler chickens (Ross breed) were divided into eleven groups such as 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 and 11 of which group 1, 3, 5, 7 and 9 were vaccinated primarily with Nobilis® MA5+Clone30, Avipro® ND-IB HB1, Cevac® BIL, Newcastle-Bronchitis Vaccine Fortdodge® and Avipro® ND LaSota vaccine respectively at day 5 of age and secondarily with Nobilis® ND Clone 30, Avipro® ND LaSota, Cevac® New L, Newcastle Disease vaccine Fortdodge® and Avipro® ND LaSota vaccine respectively at day 21 of age by single eye instillation and 2, 4, 6, 8 and 10 were vaccinated with the same vaccines respectively by double eye instillation following the same schedule. Group 11 was kept as unvaccinated control. Sera samples were collected after 10 days of each vaccination and at day 5, 15, 20, 31 of age from nonvaccinated control and subjected to HI test for the determination of antibody titres. It was observed that after primary vaccination the geometric mean (GM) of HI titres of double eye vaccinated groups differed significantly (P<0.01). Overall analysis of GM of HI titres of double eye vaccinated groups revealed that there were significant increases (P<0.01) in HI titres in groups 8 (301.07±70.10) and 10 (284.24±85.86) compared to other groups. It was observed that secondary vaccination produced higher immune response compared to primary vaccination in case of all the vaccinated groups and double eye vaccination produced higher immune response compared to single eye vaccination in case of all the vaccinated groups. Maternal antibody was high (256.00±140.21) at day 5 of age and persisted to a minimal level (5.27±2.19) until the age of day 20 and almost disappears (â¤4±0) at day 31 of age. From the present research it may be concluded that LaSota strain produced higher immune response than Clone 30 and B1 strain and Fortdodge® and Avipro® vaccine produced higher immune response than all other vaccines used in this study.

Key words: Immune response, Newcastle disease, ND vaccines, broiler chickens

doi: 10.3329/bjvm.v6i2.2326

Bangl. J. Vet. Med. (2008). 6 (2): 139-144

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Avian Medicine