COMPARATIVE IMMUNOGENICITY OF BIOTYPHOID^® AND DLS PREPARED FOWL TYPHOID VACCINE IN LAYER CHICKENS

Abstract

The experiment was conducted to investigate the immunogenicity of DLS prepared Fowl typhoid vaccine in comparison to commercially available BIO-TYPHOID^® (Imported by Advance Animal Science Co. Ltd., Bangladesh) in layer chickens. To compare the immunogenicity of these two vaccines a total of 30 chickens were divided into three groups (group A, B and C) each including 10 layer chickens of Fayoumi breed. Chickens of group A and B were vaccinated with DLS prepared fowl typhoid vaccine and BIO-TYPHOID^® respectively following usual schedule of vaccination (i.e. first dose at 42 days of age and second dose at 72 and 112 days for DLS prepared fowl typhoid vaccine and BIO-TYPHOID^® respectively) with a dose of 0.5 ml at each occasion through SC route. Birds of group C were kept as unvaccinated control. Blood samples were collected to obtain sera from each chicken at every 7 days interval up to 105 days post vaccination for determination of antibody titre following primary and secondary vaccination using Microplate Agglutination test. Highest mean antibody titres obtained from Group A and B which were 460.80 and 409.60 respectively. Among the chickens vaccinated the highest mean antibody titre of 460.80 was obtained at 56 days post vaccination from chickens in group A vaccinated with DLS prepared Fowl typhoid vaccine. Results of this study revealed that DLS prepared fowl typhoid vaccine induced higher antibody production than BIO-TYPHOID^®.

DOI = 10.3329/bjvm.v8i1.7394

Bangl. J. Vet. Med. (2010). 8(1): 01-04