COMPARATIVE EFFICACY OF NEEM (<i>AZADIRACHTA INDICA</i>) AND METFORMIN HYDROCHLORIDE (COMET<sup>&reg;</sup>) IN STREPTOZOTOCIN INDUCED DIABETES MELITUS IN RATS

Authors

  • AR Das Department of Pharmacology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh-2202
  • M Mostofa Department of Pharmacology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh-2202
  • ME Hoque Department of Pharmacology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh-2202
  • S Das Department of Pharmacology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh-2202
  • AK Sarkar Department of Pharmacology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh-2202

DOI:

https://doi.org/10.3329/bjvm.v8i1.8353

Keywords:

Diabetes mellitus hypoglycemia, body weight, blood glucose, Azadirachta Indica, metforminhydrochloride, Streptozotocin

Abstract

The present study was investigated the comparative efficacy of extract of Neem (Azadirachta indica) and Metformin hydrochloride (Comet®) in respect of their hypoglycemic activity in Streptozotocin (STZ)-induced diabetic rats. Extract of Neem was administered @ 500 mg/kg body-weight (bwt) and 250 mg/kg bwt. Metformin hydrochloride @ 500 mg/kg bwt and 250 mg/kg daily orally for 21 days. Changes in the blood glucose level and body weight were measured and the results were compared statistically using Anova test. The extract of Neem leaves and Metformin hydrochloride showed significant (p<0.01) hypoglycemic effect and neem extracts at 250 mg/kg bwt showed more potent effects. The Neem extracts significantly (p<0.01) increased body weight @ 250 mg/kg. From this experiment it was observed that extracts of Neem leaves had hypoglycemic and body weight gain effect. For definite conclusion, details study is needed.

 

DOI = 10.3329/bjvm.v8i1.8353

Bangl. J. Vet. Med. (2010). 8(1): 75-80

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Laboratory Animal Medicine