Prevalence of Peripheral Blood Neutrophilic and Eosinophilic Phenotype in Bronchiectasis Patients in Bangladesh
DOI:
https://doi.org/10.3329/cbmj.v14i2.83256Keywords:
Bronchiectasis, neutrophilic phenotype, eosinophilic phenotype, non-neutrophilic phenotype, BangladeshAbstract
Bronchiectasis is a heterogeneous condition characterized by chronic airway inflammation. Phenotypic classification into neutrophilic, eosinophilic, and non-neutrophilic types is crucial for understanding disease pathophysiology and guiding management. A cross-sectional study was conducted in the Department of Respiratory Medicine, Cumilla Medical College Hospital, Bangladesh, from January 2023 to June 2024, to assess prevalence of those phenotypes and clinical implications. A total of 150 adult bronchiectasis patients diagnosed via clinical features, high-resolution computed tomography (HRCT), and pulmonary function tests. Blood samples were analyzed to determine phenotypes: neutrophilic (ANC >7.5×10⁹/L), eosinophilic (AEC >0.3×10⁹/L), and non-neutrophilic (neither criteria met). Clinical, demographic, and radiological data were collected and analyzed. The neutrophilic phenotype was predominant (63.3%), followed by eosinophilic (23.3%) and non-neutrophilic (13.4%). Neutrophilic patients were older (mean 45.3±10.5years) and more likely to be smokers (57.9%; p=0.015). Frequent exacerbations (>2 per year) were highest in neutrophilic (68.4%; p=0.001), and severe HRCT findings were more prevalent in this group (57.9%; p=0.048). Eosinophilic patients had milder disease and fewer exacerbations (57.1%), aligning with a Th2-driven inflammatory mechanism. Logistic regression showed smoking as a significant risk factor for severe disease (OR=2.08, p=0.019). Neutrophilic bronchiectasis is the most common and severe phenotype, closely linked to smoking and frequent exacerbations. Eosinophilic and non-neutrophilic phenotypes showed milder clinical courses highlighting the need for management strategies tailored to specific phenotypes.
CBMJ 2025 July: vol. 14 no. 02 P:21-27
Downloads
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Mirza Mohammad Idris Ali, Mohammad Towfique Hasan, Mohammad Amir Hossain Miah, Pulak Kumar Dey, Mostaque Ahammad, Syeed Mehbub Ul Kadir

This work is licensed under a Creative Commons Attribution 4.0 International License.
No part of the materials published in this journal may be reproduced, stored or transmitted without prior written permission of the editorial board.