Prevalence of Peripheral Blood Neutrophilic and Eosinophilic Phenotype in Bronchiectasis Patients in Bangladesh

Authors

  • Mirza Mohammad Idris Ali Assistant Professor, Department of Respiratory Medicine, Comilla Medical College, Cumilla, Bangladesh
  • Mohammad Towfique Hasan Associate Professor, Department of Respiratory Medicine, Sir Salimullah Medical College, Dhaka, Bangladesh
  • Mohammad Amir Hossain Miah Assistant Professor, Department of Respiratory Medicine, Comilla Medical College, Cumilla, Bangladesh
  • Pulak Kumar Dey Associate Professor, Department of Respiratory Medicine, National Institute of Diseases of the Chest and Hospital, Dhaka, Bangladesh
  • Mostaque Ahammad Assistant Professor, Department of Medicine, Comilla Medical College, Cumilla, Bangladesh
  • Syeed Mehbub Ul Kadir Assistant Professor, National Institute of Ophthalmology and Hospital, Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/cbmj.v14i2.83256

Keywords:

Bronchiectasis, neutrophilic phenotype, eosinophilic phenotype, non-neutrophilic phenotype, Bangladesh

Abstract

Bronchiectasis is a heterogeneous condition characterized by chronic airway inflammation. Phenotypic classification into neutrophilic, eosinophilic, and non-neutrophilic types is crucial for understanding disease pathophysiology and guiding management. A cross-sectional study was conducted in the Department of Respiratory Medicine, Cumilla Medical College Hospital, Bangladesh, from January 2023 to June 2024, to assess prevalence of those phenotypes and clinical implications. A total of 150 adult bronchiectasis patients diagnosed via clinical features, high-resolution computed tomography (HRCT), and pulmonary function tests. Blood samples were analyzed to determine phenotypes: neutrophilic (ANC >7.5×10⁹/L), eosinophilic (AEC >0.3×10⁹/L), and non-neutrophilic (neither criteria met). Clinical, demographic, and radiological data were collected and analyzed. The neutrophilic phenotype was predominant (63.3%), followed by eosinophilic (23.3%) and non-neutrophilic (13.4%). Neutrophilic patients were older (mean 45.3±10.5years) and more likely to be smokers (57.9%; p=0.015). Frequent exacerbations (>2 per year) were highest in neutrophilic (68.4%; p=0.001), and severe HRCT findings were more prevalent in this group (57.9%; p=0.048). Eosinophilic patients had milder disease and fewer exacerbations (57.1%), aligning with a Th2-driven inflammatory mechanism. Logistic regression showed smoking as a significant risk factor for severe disease (OR=2.08, p=0.019). Neutrophilic bronchiectasis is the most common and severe phenotype, closely linked to smoking and frequent exacerbations. Eosinophilic and non-neutrophilic phenotypes showed milder clinical courses highlighting the need for management strategies tailored to specific phenotypes.  

CBMJ 2025 July: vol. 14 no. 02 P:21-27

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Published

2025-07-28

How to Cite

Ali, M. M. I., Hasan, M. T., Miah, M. A. H., Dey, P. K., Ahammad, M., & Kadir, S. M. U. (2025). Prevalence of Peripheral Blood Neutrophilic and Eosinophilic Phenotype in Bronchiectasis Patients in Bangladesh. Community Based Medical Journal, 14(2), 21–27. https://doi.org/10.3329/cbmj.v14i2.83256

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Section

Original Articles