Dexamethasone Versus Lidocaine: Evaluation of Their Roles in Reduction of Sore Throat after Endotracheal Extubation Following General Anaesthesia

Authors

  • Md Saiful Islam Assistant Professor, Department of Anaesthesiology, Green Life Medical College, Dhanmondi, Dhaka, Bangladesh
  • Lipon Kanti Bhowmick Assistant Professor, Department of Anaesthesiology and Intensive Care Unit (ICU), Community Based Medical College, Mymensingh, Bangladesh
  • Md Mashfiqur Rahman Khan Specialist (Anaesthesia, ICU and Pain Medicine), Sheikh Fazilatunnessa Mujib Memorial KPJ Specialized Hospital, Dhaka, Bangladesh
  • Mohammad Mahabubuzzaman Junior Consultant, Department of Anaesthesiology and Intensive Care Unit (ICU), NITOR, Dhaka Bangladesh
  • Md Abdur Rahim Assistant Professor, Department of Anaesthesiology and ICU, TMSS Medical College, Bogura, Bangladesh
  • Md Humayun Kabir Junior Consultant, Department of Anaesthesiology and ICU, Mugda Medical College, Dhaka, Bangladesh
  • Md Zubyeer Ali Sheikh Associate Professor, Department of Anaesthesia and critical care medicine, Khulna City Medical College, Khulna, Bangladesh

DOI:

https://doi.org/10.3329/cbmj.v15i1.87517

Keywords:

Dexamethasone, lidocaine, endotracheal extubation, postoperative sore throat, general anaesthesia

Abstract

Postoperative sore throat (POST) is a common complaint in patients requiring general anaesthesia with endotracheal intubation (ETI) for surgery. Many procedural modifications and drugs were tried to reduce such discomfort. This prospective randomized controlled study was conducted in a tertiary care hospital in Dhaka, Bangladesh, between July and December of 2024, to determine the efficacy of dexamethasone and lidocaine in reducing postoperative sore throat in patients receiving general anaesthesia with endotracheal intubation. A total of 150 patients were enrolled and divided into 3 groups in this study with 50 patients in each group. Simple Random sampling technique was used. Group D (dexamethasone) received 5 mg dexamethasone and group L (lidocaine) received 1.5 mg/kg lidocaine 30 minutes before operation. However, group C (control) did not receive any study drug. Data was collected through semi-structured questionnaire in patient data sheet and analyzed. The incidence of POST was found 30%, 38% and 52% in dexamethasone, lidocaine and control groups respectively (p<0.05). Dexamethasone reduced the incidence of POST in the first 24 hours (OR=0.4, 95% CI=0.17–0.9). However, there was no significant difference of severity of POST at 3 hours, 6 hours, 12 hours and 24 hours (p>0.05) after extubation. To conclude, intravenous dexamethasone was found more effective than intravenous lidocaine in reducing the incidence of postoperative sore throat after endotracheal extubation following general anaesthesia.  

CBMJ 2026 January: vol. 15 no. 01 P:10-16

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Published

2026-02-05

How to Cite

Islam, M. S., Bhowmick, L. K., Khan, M. M. R., Mahabubuzzaman, M., Rahim, M. A., Kabir, M. H., & Sheikh, M. Z. A. (2026). Dexamethasone Versus Lidocaine: Evaluation of Their Roles in Reduction of Sore Throat after Endotracheal Extubation Following General Anaesthesia. Community Based Medical Journal, 15(1), 10–16. https://doi.org/10.3329/cbmj.v15i1.87517

Issue

Vol. 15 No. 1 (2026)

Section

Original Articles

License

Copyright (c) 2026 Md Saiful Islam, Lipon Kanti Bhowmick, Md Mashfiqur Rahman Khan, Mohammad Mahabubuzzaman, Md Abdur Rahim, Md Humayun Kabir, Md Zubyeer Ali Sheikh

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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