Hypertension and Serum C-Reactive Protein Levels in Pre-eclampsia

Authors

  • Kazi Sadeka Ruma Junior Consultant, Department of Obstetrics & Gynaecology, Shaheed Suhrawardy Medical College Hospital, Dhaka-1207, Bangladesh
  • Begum Sultana Hasina Rashed Assistant Professor, Department of Obstetrics & Gynaecology, Shaheed Suhrawardy Medical College & Hospital, Dhaka-1207, Bangladesh
  • Jannatul Ferdous Junior Consultant, Department of Obstetrics & Gynaecology, Shaheed Suhrawardy Medical College & Hospital, Dhaka-1207, Bangladesh
  • Tanvina Akhter Junior Consultant, Department of Obstetrics & Gynaecology, Shaheed Suhrawardy Medical College & Hospital, Dhaka-1207, Bangladesh
  • Farjana Maksurat Junior Consultant, Department of Obstetrics & Gynaecology, Shaheed Suhrawardy Medical College & Hospital, Dhaka-1207, Bangladesh
  • Nushrat Jahan Urmy Research Associate, BRAC James P Grant School of Public Health, Dhaka-1212, Bangladesh

DOI:

https://doi.org/10.3329/cbmj.v15i1.87557

Keywords:

C-reactive protein, hypertension in pregnancy, pre-eclampsia

Abstract

A case-control study was carried out in the Department of Obstetrics & Gynaecology of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, between January 2013 and June 2014, to see the association of hypertension and C-reactive protein (CRP) levels in pre-eclampsia patients. A total of 78 patients were enrolled in the study. Patients were divided into three groups: group-I included of 26 pregnant women with mild pre-eclampsia, while group-II had 26 pregnant women with severe pre-eclampsia and group-III had 26 women with normal pregnancy. Group-I and group-II were together considered as ‘case’, while group-III was considered as ‘control’. We adopted a convenient sampling technique. For each patient, after a 10-minute of resting phase, blood pressure was measured following standard procedure. C-reactive protein (CRP) was measured from patients’ serum based on latex particle-enhanced nephelometric immunoassay using CardioPhase® High Sensitivity CRP kit. The mean systolic BP was found 155.0±13.7 mmHg in group-I+group-II (case group) (i.e., mild and severe pre-eclampsia), while 108.46±0.8 mmHg in group III (control group). Similarly, the mean diastolic BP was found 102.31±9.7 mmHg in group-I+group-II and 68.46±7.8 mmHg in group-III. The differences were statistically significant (p=0.001). The mean CRP level was found 23.82±21.8 mg/L in group-I+group-II (case group) and 4.42±0.9 mg/L in group-III (control group). The difference was statistically significant (p=0.001). A positive significant correlation was found between systolic blood pressure and CRP level, as of Pearson's correlation coefficient r=0.439 (p=0.025) and r=0.434 (p=0.027) in mild and severe pre-eclampsia respectively. Similarly, a positive significant correlation was found between diastolic blood pressure and CRP level, as of Pearson's correlation coefficient r=0.446 (p=0.022) and r=0.440 (p=0.024) in mild and severe pre-eclampsia respectively.  

CBMJ 2026 January: vol. 15 no. 01 P:50-55

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Published

2026-02-05

How to Cite

Ruma, K. S., Rashed, B. S. H., Ferdous, J., Akhter, T., Maksurat, F., & Urmy, N. J. (2026). Hypertension and Serum C-Reactive Protein Levels in Pre-eclampsia. Community Based Medical Journal, 15(1), 50–55. https://doi.org/10.3329/cbmj.v15i1.87557

Issue

Vol. 15 No. 1 (2026)

Section

Original Articles

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Copyright (c) 2026 Kazi Sadeka Ruma, Begum Sultana Hasina Rashed, Jannatul Ferdous, Tanvina Akhter, Farjana Maksurat, Nushrat Jahan Urmy

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