Assessment of Pharmacological Properties of Mimosa Diplotricha Leaf Extract

Abstract

This present study was designed to explore the different pharmacological activities of methanol extracts of Mimosa diplotricha leaves (MDME) and its chloroform (MDCH), n-hexane (MDNH), pet ether (MDPE), and aqueous (MDAQ) fractions. The antidiarrheal activity was investigated by the castor oil-induced diarrhea method. The thrombolytic activity was done using in vitro clot lysis model. The anthelmintic activity was conducted on the earthworm Pheretima posthuma and the antimicrobial activity was evaluated by the disc diffusion method. In the castor oil-induced model, the MDME (200 mg/kg) exhibited significant (p<0.001) inhibition in the total number of defecations within the testing period compared to standard loperamide (p<0.001). During the clot lysis procedure, MDME and MDCH (20 mg/ml) exhibited significant (p<0.001) clot lysis (%) compared with standard streptokinase. In the anthelmintic procedure, MDME and MDAQ (50 mg/ml) showed significant anthelmintic activity in a concentration-dependent manner, while the standard drug albendazole (15 mg/ml) provided significant anthelmintic activity. In the disc diffusion method, MDME provides no antimicrobial activity. So, our study revealed that the plant extracts have potential antidiarrheal, thrombolytic, and anthelmintic activities.

 The Chittagong Univ. J. B. Sci. Vol. 11 (1 & 2): 42-51, 2023