Comparison of Effect of Silymarin and Ethanol Extract of Trigonella foenum-graecum on Gentamicin Induced Nephrotoxicity in Rats

Authors

  • Syeda Rubayat Hilmi Assistant Professor, Department of Pharmacology, ZH Sikder Women’s Medical College, Dhaka, Bangladesh
  • Zesmin Fauzia Dewan Professor, Department of Pharmacology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
  • AKM Nurul Kabir Associate Professor, Department of Pathology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
  • Muhammad Moinul Islam Indoor Medical Officer, Department of Cardiac Surgery, Dhaka Medical College & Hospital, Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/jcamr.v6i1.40779

Keywords:

Trigonella foenum-graecum; silymarin; gentamicin; nephrotoxicity

Abstract

Background: A variety of drugs and chemicals possess nephrotoxic potentials; therefore it is of keen interest to the researchers to obtain ways and means for alleviation of nephrotoxicity.

Objective: The present study was designed to compare the ameliorative effect of silymarin with ethanol extract of Trigonella foenum-graecum in an experimental model of gentamicin- induced nephrotoxic rats.

Methodology: This animal study was conducted by giving distilled water intraperitoneally to control group for seven days (1ml/rat/day) and was sacrificed on 8th day. To induce nephrotoxicity, gentamicin (GM) was administered (80 mg/kg/day for 7 days) intraperitoneally and sacrificed on 15th day. The ethanol extract of T. foenum-graecum was administered (500 mg/kg/day for 14 days) orally concomitantly with GM (7 days) and sacrificed on 15th day. To another group of rats, silymarin was administered (500 mg/kg/day for 14 days) orally concomitantly with gentamicin (7 days) and sacrificed on the 15th day. Biochemical indices like serum creatinine and serum urea levels were estimated to determine nephrotoxicity and amelioration of nephrotoxicity in all rat groups. To determine the status of oxidative stress and lipid peroxidation, the renal cortical glutathione (GSH) and renal cortical malondialdehyde (MDA) levels were estimated.

Results: Statistically significant amelioration was observed in all the biochemical parameters in T. foenum-graecum and silymarin treated groups.

Conclusion: The ameliorating effect of T. foenum-graecum is much more effective in comparison to that of silymarin in nephrotoxicity.

Journal of Current and Advance Medical Research 2019;6(1):23-27

Downloads

Download data is not yet available.
Abstract
31
PDF
28

Downloads

Published

2019-03-27

How to Cite

Hilmi, S. R., Dewan, Z. F., Kabir, A. N., & Islam, M. M. (2019). Comparison of Effect of Silymarin and Ethanol Extract of Trigonella foenum-graecum on Gentamicin Induced Nephrotoxicity in Rats. Journal of Current and Advance Medical Research, 6(1), 23–27. https://doi.org/10.3329/jcamr.v6i1.40779

Issue

Vol. 6 No. 1 (2019)

Section

Original Articles

License

Copyright on any research article in the Journal of Current and Advance Medical Research is retained by the author(s).

The authors grant the Journal of Current and Advance Medical Research a license to publish the article and identify itself as the original publisher.

Articles in the Journal of Current and Advance Medical Research are Open Access articles published under the Creative Commons CC BY-NC License (https://creativecommons.org/licenses/by-nc/4.0/)

This license permits use, distribution and reproduction in any medium, provided the original work is properly cited, and it is not used for commercial purposes.