Synthesis and DFT Studies of Glucopyranoside Dipentanoyl Esters

Authors

  • MM Matin Bioorganic and Medicinal Chemistry Laboratory, Department of Chemistry, University of Chittagong, Chittagong, 4331, Bangladesh

DOI:

https://doi.org/10.3329/jscitr.v3i1.62803

Keywords:

Regioselective acylation; 2,6-Di-O-pentanoyl-α- D-glucopyranoside; PASS predication; DFT calculation; Molecular docking; SARS-CoV-2 main protease

Abstract

Sugar esters (SEs) with potential antimicrobial activity were found to be a better choice to solve the multidrug resistant (MDR) pathogens due to their less side-effect. In this respect, regioselective dimolar pentanoylation of methyl α-D-glucopyranoside using direct method furnished the 2,6-di-O-pentanoate indicating more reactivity of C-6 and C-2 hydroxyl groups. To develop glucopyranoside based potential antimicrobial agents, the dipentanoate product was further converted into four newer 3,4-di-O-acyl esters reasonably in good yields. Prediction of activity spectra for substances (PASS) indicated them as better antifungals than antibacterials as well as more potent anticarcinogenic agents than the antioxidant agents. These observations were rationalized by DFT based thermodynamic and docking studies with fungal CYP51 (4UYL) and SARS-CoV-2 main protease (6LU7).

J. of Sci. and Tech. Res. 3(1): 11-22, 2021

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Published

2022-11-30

How to Cite

Matin, M. (2022). Synthesis and DFT Studies of Glucopyranoside Dipentanoyl Esters. Journal of Science and Technology Research, 3(1), 11–22. https://doi.org/10.3329/jscitr.v3i1.62803

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