Role of Kisspeptin in Female Infertility

Authors

  • Md Rafiqul Islam Bhuiyan Junior embryologist, Dept. of IVF, Apollo hospitals, Dhaka
  • SM Khaliduzzaman Embryologist, Dept. of IVF Apollo hospitals, Dhaka
  • Khairun Nahar Priti Medical officer, Islami Bank hospital, Dhaka

DOI:

https://doi.org/10.3329/pulse.v8i1.28101

Abstract

Background: Kiss1, a noble G protein coupled receptor designated as GPR54, was first identified in rat brain in 1999 and orthologue gene identified in human in 2001 the original niche for the function of kisspeptin was restricted to cancer biology for their ability to suppress tumor metastasis. However, kisspeptin has recently emerged as a key player in the field of reproductive endocrinology.

Method: A systematic literature review was done by using PUBMED. Though there is lack of human data, used animal data also hold translational potential for human. Results: Inactivating mutation of GPR54 gene is linked with absence of puberty onset and idiopathic hypogonadotrophic hypogonadism. Furthermore, recent studies support critical role of kisspeptin/GPR54 system on regulation of GnRH neurons, involvement of puberty onset and gonadal steroid feedback.

Conclusion: This review will briefly discuss on cellular and molecular level of kisspeptin, their potential effects on human and clinical application of kisspeptin on human reproductive disorder.

Pulse Vol.8 January-December 2015 p.43-50

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Author Biography

Md Rafiqul Islam Bhuiyan, Junior embryologist, Dept. of IVF, Apollo hospitals, Dhaka



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Published

2016-06-06

How to Cite

Bhuiyan, M. R. I., Khaliduzzaman, S., & Priti, K. N. (2016). Role of Kisspeptin in Female Infertility. Pulse, 8(1), 43–50. https://doi.org/10.3329/pulse.v8i1.28101

Issue

Section

Review Articles