Serum Lipid Profile in Ischemic Heart Disease: A Cross-Sectional Analytical Study

Authors

  • BA Ferdous Dept of Biochemistry, Marks Medical College, Dhaka
  • N Sultana Dept of Biochemistry, Dhaka Medical College, Dhaka
  • S Ahmed Dept of Biochemistry, Popular Medical College, Dhaka
  • EH Khan Dept of ENT, Holly Family Red Crescent Medical College Hospital, Dhaka
  • S Sultana Dept of Biochemistry, Marks Medical College, Dhaka
  • T Parvin Dept of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka

DOI:

https://doi.org/10.3329/bjmb.v7i1.18574

Keywords:

Myocardial infarction, total cholesterol (TC), triacylglycerol, high density lipoprotein (HDL-C) cholesterol, low density lipoprotein (LDL-C) cholesterol

Abstract

Risk of coronary heart disease and other forms of atherosclerotic vascular diseases, rises with plasma cholesterol concentration and in particular with the rise of ratio of total cholesterol to high density lipoprotein (HDL-C) cholesterol. A much weaker correlation also exists with plasma triglyceride concentration. Extensive large-scale randomized trials have shown that lowering total cholesterol and LDL-C concentrations reduces the risk of cardiovascular events including death, myocardial infarction and stroke and reduces the need for revascularisation.This cross-sectional analytical study was designed to observe association between lipid profile level with chronic ischaemic heart disease and the study was conducted in the Department of Biochemistry, Dhaka Medical College, Dhaka from July 2010 to June 2011. A total of 50 cases were selected purposively according to the selection criteria from the patients admitted in the Department of Cardiology, Dhaka Medical College Hospital with chronic ischaemic heart disease (IHD). Diagnosed IHD patients were taken as cases and 50 age- & sex- matched healthy subjects were taken as controls. Serum TC, TG, LDL-C & HDL-C were measured in all study subjects.The mean±SD of serum TC, TG, HDL-C and LDL-C concentration in cases were 314.54±73.72 mg/dl, 288.04±60.45 mg/dl, 36.02±4.12 mg/dl, and 178.62±22.7 mg/dl respectively and in controls were 174.64±18.97 mg/dl, 119.42±12.47 mg/dl, 43.04±2.58 mg/dl & 126.28±11.45 mg/dl respectively. Serum Total Cholesterol, TG & LDL-C were found to be significantly higher in cases than that of controls. Serum HDL-C was found to be significantly lower in cases than that of controls. The present study reveals that the patients with chronic ischemic heart disease is accociated with significantly higher levels of serum TC, TG and LDL-C whereas HDL-C was found to be lower in IHD patients.

DOI: http://dx.doi.org/10.3329/bjmb.v7i1.18574

Bangladesh J Med Biochem 2014; 7(1): 14-16

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Published

2014-04-11

How to Cite

Ferdous, B., Sultana, N., Ahmed, S., Khan, E., Sultana, S., & Parvin, T. (2014). Serum Lipid Profile in Ischemic Heart Disease: A Cross-Sectional Analytical Study. Bangladesh Journal of Medical Biochemistry, 7(1), 14–16. https://doi.org/10.3329/bjmb.v7i1.18574

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Section

Original Articles