Association of serum vitamin D and parathormone levels in patients of type 2 diabetes mellitus with diabetic retinopathy

Authors

  • Mohammad Shiblee Zaman Department of Biochemistry and Molecular Biology, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka
  • Md. Matiur Rahman Department of Biochemistry and Molecular Biology, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka
  • Subrata Kumar Biswas Department of Biochemistry and Molecular Biology, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka
  • Md. Mozammel Hoque Department of Biochemistry and Molecular Biology, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka
  • Khondakar Alwan Nahid Department of Biochemistry and Molecular Biology, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka

DOI:

https://doi.org/10.3329/bsmmuj.v10i2.32287

Keywords:

Diabetes mellitus, Diabetic retinopathy, Parathormone, Vitamin D

Abstract

The present study was aimed to evaluate the association of serum 25-hydroxy vitamin D and parathormone in 46 patients of type 2 diabetes mellitus with diabetic retinopathy [non-proliferative, (n=27); proliferative (n=19)]. Twenty one diabetic patients without retinopathy were taken as control. Serum 25-hydroxy vitamin D and intact parathyroid hormone were measured by chemiluminescence microparticle immunoassay. Concentration of 25-hydroxy vitamin D differed significantly among groups (p=0.018) and it was significantly lower in proliferative diabetic retinopathy than no diabetic retinopathy (p=0.003). Logistic regression analysis revealed that vitamin D deficiency [25-hydroxy vitamin D <20 ng/mL] was indepen-dently associated with development of diabetic retinopathy (p=0.007, OR 20.90, 95%CI 2.33-187.23). In conclusion, vitamin D deficiency is associated with diabetic retinopathy complicating type 2 diabetes mellitus.

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Author Biographies

Md. Matiur Rahman, Department of Biochemistry and Molecular Biology, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka

Associate Professor

Subrata Kumar Biswas, Department of Biochemistry and Molecular Biology, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka

Associate Professor

Md. Mozammel Hoque, Department of Biochemistry and Molecular Biology, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka

Professor and Chairman

Additional Files

Published

2017-05-22

How to Cite

Zaman, M. S., Rahman, M. M., Biswas, S. K., Hoque, M. M., & Nahid, K. A. (2017). Association of serum vitamin D and parathormone levels in patients of type 2 diabetes mellitus with diabetic retinopathy. Bangabandhu Sheikh Mujib Medical University Journal, 10(2), 61–65. https://doi.org/10.3329/bsmmuj.v10i2.32287

Issue

Section

Original Articles