When leaders fail: Exploring the role of dysfunctional leader cells in autoimmune disease pathogenesis

Authors

  • Falah Hasan Obayes AL-Khikani Department of Medical Laboratory Technology, College of Medical Technology, The Islamic University, Najaf, Iraq https://orcid.org/0000-0002-8890-7090

DOI:

https://doi.org/10.3329/bsmmuj.v18i2.79761

Keywords:

leader cell, autoimmune disorders, dysfunction

Abstract

Not available

Downloads

Download data is not yet available.
Abstract
41
Article text
14 PDF
15 Review report
6

References

Friedl P, Gilmour D. Collective cell migration in morphogenesis, regeneration and cancer. Nat Rev Mol Cell Biol. 2009 Jul;10(7):445-457. doi: https://doi.org/10.1038/nrm2720

Trepat X, Sahai E. Mesoscale physical principles of collective cell organization. Nat Phys. 2018;14(7):671 - 682. doi: https://doi.org/10.1038/s41567-018-0194-9

Cusick MF, Libbey JE, Fujinami RS. Molecular mimicry as a mechanism of autoimmune disease. Clin Rev Allergy Immunol. 2012 Feb;42(1):102-111. doi: https://doi.org/10.1007/s12016-011-8294-7

Rock KL, Latz E, Ontiveros F, Kono H. The sterile inflammatory response. Annu Rev Immunol. 2010;28:321-342. doi: https://doi.org/10.1146/annurev-immunol-030409-101311

Roh JS, Sohn DH. Damage-Associated Molecular Patterns in Inflammatory Diseases. Immune Netw. 2018 Aug 13;18(4):e27. doi: https://doi.org/10.4110/in.2018.18.e27

Colombo M, Raposo G, Théry C. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu Rev Cell Dev Biol. 2014;30:255-289. doi: https://doi.org/10.1146/annurev-cellbio-101512-122326

Wynn TA, Vannella KM. Macrophages in tissue repair, regeneration, and fibrosis. Immunity. 2016 Mar 15;44(3):450-462. doi: https://doi.org/10.1016/j.immuni.2016.02.015

Salem V, Silva LD, Suba K, Georgiadou E, Neda Mousavy Gharavy S, Akhtar N, Martin-Alonso A, Gaboriau DCA, Rothery SM, Stylianides T, Carrat G, Pullen TJ, Singh SP, Hodson DJ, Leclerc I, Shapiro AMJ, Marchetti P, Briant LJB, Distaso W, Ninov N, Rutter GA. Leader β-cells coordinate Ca2+ dynamics across pancreatic islets in vivo. Nat Metab. 2019 Jun;1(6):615-629. doi: https://doi.org/10.1038/s42255-019-0075-2

Chernysheva МB, Ruchko ЕS, Karimova МV, Vorotelyak ЕA, Vasiliev АV. Development, regeneration, and physiological expansion of functional β-cells: Cellular sources and regulators. Front Cell Dev Biol. 2024 Jul 9;12:1424278. doi: https://doi.org/10.3389/fcell.2024.1424278

Li L, He Y, Zhao M, Jiang J. Collective cell migration: Implications for wound healing and cancer invasion. Burns Trauma. 2013 Jun 18;1(1):21-26. doi: https://doi.org/10.4103/2321-3868.113331

Published

2025-06-16

How to Cite

AL-Khikani, F. H. O. (2025). When leaders fail: Exploring the role of dysfunctional leader cells in autoimmune disease pathogenesis. Bangabandhu Sheikh Mujib Medical University Journal, 18(2), e79761. https://doi.org/10.3329/bsmmuj.v18i2.79761

Issue

Section

Commentary

Similar Articles

1 > >> 

You may also start an advanced similarity search for this article.