Serum concentration of folate, vitamin B<sub>12</sub> and homocysteine in patients of cervical cancer

Authors

  • Jannatul Ferdous Division of Gynecological Oncology, Department of Obstetrics and Gynecology, Faculty of Surgery, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, Dhaka
  • Sabera Khatun Division of Gynecological Oncology, Department of Obstetrics and Gynecology, Faculty of Surgery, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, Dhaka
  • Subrata Kumar Biawas Department of Biochemistry, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, Dhaka
  • Latifa Akter Division of Gynecological Oncology, Department of Obstetrics and Gynecology, Faculty of Surgery, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, Dhaka
  • Kashfia Ahmed Keya Division of Gynecological Oncology, Department of Obstetrics and Gynecology, Faculty of Surgery, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, Dhaka

DOI:

https://doi.org/10.3329/bsmmuj.v9i4.30104

Keywords:

Cervical cancer, Folate, Homocysteine, Vitamin B12

Abstract

The aim of this study was to evaluate the risk of cervical cancer in relation to serum concentration of folate, vitamin B12 and homocysteine. Fifty patients with invasive cervical cancer and 50 VIA negative cases (control) with age range of 30-65 years were included. Majority of the patients had significantly low level of serum folate and B12 than those in the control group.  In contrast, serum homocysteine level was significantly high in cases than those in the control group. The Pearson correlation coefficient test showed a significant negative relationship between serum folate, vitamin B12 and serum homocyteine. However, there was no significant association between stage of cervical cancer and level of serum homocysteine. In conclusion, a significantly low level of serum folate, vitamin B12 and high level of serum homocysteine were observed in patients with invasive cervical cancer.

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Author Biographies

Jannatul Ferdous, Division of Gynecological Oncology, Department of Obstetrics and Gynecology, Faculty of Surgery, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, Dhaka

Associate Professor

Sabera Khatun, Division of Gynecological Oncology, Department of Obstetrics and Gynecology, Faculty of Surgery, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, Dhaka

Professor

Subrata Kumar Biawas, Department of Biochemistry, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, Dhaka

Associate Professor

Latifa Akter, Division of Gynecological Oncology, Department of Obstetrics and Gynecology, Faculty of Surgery, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, Dhaka

Medical Officer

Kashfia Ahmed Keya, Division of Gynecological Oncology, Department of Obstetrics and Gynecology, Faculty of Surgery, Bangabandhu Sheikh Mujib Medical University, Kazi Nazrul Islam Avenue, Shahbag, Dhaka

Colposcoipist

Published

2016-12-05

How to Cite

Ferdous, J., Khatun, S., Biawas, S. K., Akter, L., & Keya, K. A. (2016). Serum concentration of folate, vitamin B<sub>12</sub> and homocysteine in patients of cervical cancer. Bangabandhu Sheikh Mujib Medical University Journal, 9(4), 188–192. https://doi.org/10.3329/bsmmuj.v9i4.30104

Issue

Section

Original Articles