Analysis of the association between Epstein Barr virus infection and Hodgkin lymphoma

Authors

  • Jasmine Akhter Jahan Lecturer, Department of Pathology, Mugda Medical College, Dhaka https://orcid.org/0000-0002-3470-9822
  • S M Rashed Ul Islam Associate Professor, Department of Virology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka https://orcid.org/0000-0002-8164-5905
  • Md Shafikul Alam Tanim Assistant Professor, Department of Pathology, US Bangla Medical College and Hospital, Narayanganj.
  • Tasnim Binte Ahmed Lecturer, Department of Pathology, Mugda Medical College, Dhaka,
  • Md Rabiul Alam Assistant Registrar, Department of Nephrology, National Institute of Kidney Diseases and Urology (NIKDU), Dhaka
  • Ferdousy Begum Professor and Chairman, Department of Pathology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka

DOI:

https://doi.org/10.3329/bsmmuj.v15i4.64225

Keywords:

epstein barr virus, hodgkin lymphoma, latent membrane protein 1, viral capsid antigen IgG

Abstract

Epstein Barr virus plays an important role in the pathogenesis of Hodgkin lymphoma. However, the frequency of its association in Bangladeshi people has not been widely studied. The aim of this study was to determine the association of Epstein Barr virus association in Hodgkin Lymphoma through detection of Latent Membrane Protein 1 by immunohistochemistry and serum Epstein Barr virus viral capsid antigen IgG antibody titer by serology. This was a cross-sectional study in purposively selected 45 histologically diagnosed cases of Hodgkin lymphoma at Bangabandhu Sheikh Mujib Medical University, Dhaka, during the period of March 2017 to December 2018. Latent membrane protein 1 was positive in 71.1% of cases of Hodgkin lymphoma. Among these positive cases, 96% of cases had significantly raised titer of serum Epstein Barr virus viral capsid antigen IgG antibody (P<0.0001 obtained by Fisher’s Exact test), which had a male predominance. Mixed cellularity classical Hodgkin lymphoma showed the highest positivity.

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Published

2023-02-05

How to Cite

Jahan, J. A. ., Islam, S. M. R. U. ., Tanim, M. S. A. ., Ahmed, T. B. ., Alam, M. R. ., & Begum, F. . (2023). Analysis of the association between Epstein Barr virus infection and Hodgkin lymphoma. Bangabandhu Sheikh Mujib Medical University Journal, 15(4), 32–36. https://doi.org/10.3329/bsmmuj.v15i4.64225

Issue

Vol. 15 No. 4 (2022)

Section

Brief Article

License

Copyright (c) 2022 Jasmine Akhter Jahan, S M Rashed Ul Islam, Md Shafikul Alam Tanim, Tasnim Binte Ahmed, Md Rabiul Alam, Ferdousy Begum

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.