Association of vitamin D level with systemic lupus erythematosus: A case-control study

Authors

  • Mrinal Saha Critical Care Medicine, Chittagong Medical College Hospital, Chattogram, Bangladesh https://orcid.org/0000-0003-0682-9779
  • Aparana Deb Department of Medicine, Chittagong Medical College Hospital, Chattogram, Bangladesh, Email: deb.aparna84@gmail.com
  • Imtiaz Sultan Department of Medicine, Chittagong Medical College, Chattogram, Bangladesh, Email: imtizsultan73@gmail.com
  • Md Abdur Razzaque Department of Rheumatology, Chittagong Medical College, Chattogram, Bangladesh, Email: rhrazzaq@gmail.com https://orcid.org/0000-0002-2395-542X
  • Sakit Mahmud Directorate General of Health Service, Dhaka, Bangladesh https://orcid.org/0009-0001-1325-9519
  • Abu Kamran Rahul Department of Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh, Email: rahul@bsmmu.edu.bd
  • Khaled Hassan Department of Endocrinology, Sheikh Hasina National Institute of Burn and Plastic Surgery, Dhaka, Bangladesh, Email: ommee.smc@gmail.com https://orcid.org/0000-0003-4838-0033
  • Sujat Paul Marine City Medical College, Chattogram, Bangladesh, Email: dr.sujatpaul@gmail.com

DOI:

https://doi.org/10.3329/bsmmuj.v16i4.68428

Keywords:

SLE, systemic lupus erythematosus, vitamin D deficiency

Abstract

Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune connective tissue disease. SLE patients are more prone to vitamin D deficiency because of their light sensitivity, renal involvement, and prolonged steroid use. This current study aimed to determine the relationship between vitamin D deficiency and SLE.

Methods: In this case-control study, 50 SLE patients (cases) and 50 healthy people (controls) were recruited. The reference value of vitamin D is as follows: normal ≥ 30 ng/ml, deficient ≤ 20 ng/ml, and insufficient 21–29 ng/ml.

Results: The mean (standard deviation) of vitamin D levels in SLE patients was 19.5 (5.3) ng/mL, which was significantly lower than those in healthy controls, 27.3 (10.0) ng/mL (P<0.001). The healthy controls had a higher proportion of people with normal vitamin D levels (≥ 30 ng/ml). We noticed a moderate negative correlation between vitamin D levels and fatigability, while a moderate positive correlation was seen with hemoglobin levels and the duration of sun exposure. However, in multiple logistic regression analysis, all the associations mentioned above disappeared.

Conclusion: Although vitamin deficiency was found to be associated with SLE, its relationship disappears when the confounding by other variables is considered in the analysis. 

Downloads

Published

2023-11-28

How to Cite

Saha, M., Deb, A., Sultan, I., Razzaque, M. A., Mahmud, S., Rahul, A. K., … Paul, S. (2023). Association of vitamin D level with systemic lupus erythematosus: A case-control study. Bangabandhu Sheikh Mujib Medical University Journal, 16(4). https://doi.org/10.3329/bsmmuj.v16i4.68428

Issue

Section

Brief Article

Similar Articles

1 > >> 

You may also start an advanced similarity search for this article.