Effect of raised serum uric acid level on perinatal and maternal outcome in cases of pregnancy-induced hypertension

Abstract

The aim of this study was to find out the effects of raised serum uric acid level on perinatal and maternal outcome in cases of pregnancy-induced hypertension. One hundred pregnant women with gestational period beyond 28 weeks with pregnancy-induced hypertension-preeclampsia and eclampsia were included in this study and divided into two groups. Group A (n=65) patients with a serum uric acid level >6 mg/dL was compared to Group B (n=35) patients with a uric acid level <6 gm/dL. It revealed that high uric acid level in patients with pregnancy-induced hypertension was a risk factor for several maternal complications like postpartum hemorrhage (Group A, 12 cases; Group B, 7 cases), postpartum eclampsia (Group A, 7 cases; Group B, 3 cases), abruptio placentae (Group A, 6 cases; Group B, 2 cases), HELLP syndrome (Group A, 2 cases; Group B, no case) and pulmonary edema (Group A, 3 cases; Group B, no case). In case of perinatal outcome, the birth weight, intrauterine growth retardation, intrauterine death, stillbirth and neonatal death rate were worse in Group A 1.9 kg, 46, 19, 7 and 8 cases in comparison to Group B, where those were 2.1, 13, 6, 2, and 2 cases respectively. In conclusion, high uric acid in blood in patient with hypertensive disorders in pregnancy is a risk factor for several maternal complications.