Association of serum vitamin D3 with newly diagnosed type 2 diabetes mellitus

Abstract

Vitamin D has an important role and supposed to be a risk factor in the development of pathogenesis of type 2 diabetes mellitus by affecting either insulin sensitivity or β-cell function, or both. The present study was conducted to evaluate the relation of serum vitamin D₃  and type 2 diabetes mellitus. Total 80 individuals were enrolled in this study. Forty newly diagnosed type 2 diabetic individual were enrolled as cases and 40 healthy glucose tolerant subjects were enrolled as controls. Serum vitamin D₃ was measured by chemiluminescence microparticle immunoassay. Fasting and 2 hours plasma glucose level were measured by hexokinase method using the Dimension clinical chemistry system. The mean serum vitamin D₃ level was significantly low in type 2 diabetes mellitus than in controls (p= 0,007). The individual with vitamin D₃ deficiency showed 3.4 times higher chances to develop type 2 diabetes mellitus compare to the individual with normal vitamin D status. Correlation test showed significant (r= -0.351) negative correlation (p=0.026)  between serum vitamin D₃ and type 2 diabetes mellitus. It can be concluded that vitamin D₃ deficiency is related to type 2 diabetes mellitus.